Police are searching for a driver who fled on foot after more than a dozen people sustained injuries in a crash on the Gardiner Expressway.

Police and emergency crews were called on January 12 to the westbound lanes of the highway near Islington Avenue, just before 9 p.m., after reports of a multi-vehicle collision involving a GO Transit bus.

Police say it appears a car had been speeding and interacted with other vehicles before it flipped over.

Another vehicle swerved to avoid the car and hit a GO Bus carrying passengers.

Police say the driver of the flipped car, who may have been wounded, fled the scene on foot.

Another driver became trapped in their vehicle and had to be extricated at the scene.

None of the 16 people checked for injuries at the scene were taken to hospital.

The missing driver is the second in just over three months to flee on foot following a bad crash on the Gardener.

Last October the driver of an Audi bolted after a crash that left a 58-year-old woman dead and another person injured.

That collision happened nearby at the exit for Islington Avenue.

In that crash, a driver of a white 2015 Audi R8 sports car rear-ended a grey Nissan, causing the Nissan to hit the median guard rail and flip over also leaving a woman trapped.

Both drivers who took off are still on the run.